Craf1 (traf-3) isoforms and uses thereof

摘要

The present invention provides an isolated CRAF1 peptide encoded by the nucleic acid sequence shown from base 169 to base 2381 of Figures 1A-1P or a variant thereof. One embodiment of the present invention is an isoform of the CRAF1 peptide. The present invention also provides for a method of inhibiting activation by CD40 ligand of cells expressing CD40 on the cell surface, comprising providing the cells with the CRAF1 peptide or variant thereof, the peptide being present in an amount effective to inhibit activation of the cells. The present invention further provides for a method of treating a condition characterized by an aberrant or unwanted level of CD40-mediated intracellular signalling, in a subject, comprising providing the subject with a therapeutically effective amount of a peptide of this invention capable of inhibiting CD40-mediated intracellular signalling in cells bearing CD40 on the cell surface.