ANTI-TUMOUR AGENT

摘要

An anti-tumour agent comprises a macromolecular carrier moiety, an active alkylating moiety which is a nitrogen mustard and a stabilising moiety which links the active alkylating moiety with the carrier moiety. The stabilising moiety is an oligopeptide which is capable of being cleaved by a tumour-associated protease and which stabilises the active alkylating moiety by electron withdrawal and/or by inducing formation of aggregates.