发明名称 |
INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE |
摘要 |
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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申请公布号 |
CA2249615(A1) |
申请公布日期 |
1997.10.09 |
申请号 |
CA19972249615 |
申请日期 |
1997.04.01 |
申请人 |
MERCK & CO., INC.;MERCK & CO., INC. |
发明人 |
DINSMORE, CHRISTOPHER;GOMEZ, ROBERT;ANTHONY, NEVILLE;STOKKER, GERALD E. |
分类号 |
A61K31/00;A61K31/415;A61K31/4164;A61K31/44;A61K31/4409;A61P13/00;A61P13/12;A61P27/00;A61P27/02;A61P31/00;A61P31/10;A61P31/12;A61P35/00;C07D213/57;C07D233/54;C07D233/56;C07D233/61;C07D233/70;C07D401/14;C07D403/10;C07D403/14;C07D409/10;C07D409/14;C07D413/06;C07D417/06;C07D417/14;(IPC1-7):C07D233/64;C07D403/00;C07D207/04;C07D233/04;C07D277/30;C07D263/32;A61K31/40;A61K31/41;A61K31/495;A61K31/535;A61K31/54;A61K31/55 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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