CARDIOTROPHIN AND USES THEREFOR

摘要

Isolated CT-1, isolated DNA encoding CT-1, and recombinant or synthetic methods of preparing CT-1 are disclosed. CT-1 is shown to bind to and activate the receptor, LIFR beta . These CT-1 molecules are shown to influence hypertrophic activity, neurological activity, and other activities associated with receptor LIFR beta . Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, neurological disorders, and other disorders associated with the LIFR beta .