Vaccines against Aujeszky's disease and other animal diseases containing pseudorabies virus mutants

摘要

PCT No. PCT/NL93/00146 Sec. 371 Date Jan. 9, 1995 Sec. 102(e) Date Jan. 9, 1995 PCT Filed Jul. 8, 1993 PCT Pub. No. WO94/01573 PCT Pub. Date Jan. 20, 1994The invention provides vaccines for preventing and controlling animal diseases, comprising a pseudorabies virus containing glycoprotein gp50 and having a mutation in its gp50 gene. The vaccines are suitable for use against Aujeszky's disease (pseudorabies), or against other animal diseases when the mutation is an insertion comprising a heterologous gene encoding an antigen corresponding to said animal disease. The pseudorabies virus may additionally have at least one mutation in one of its other genes, such as the gp63 gene or the gI gene. The vaccines are unable to spread from vaccinated to non-vaccinated animals.