Quaternary ammonium salts of aromatic amine compounds, their preparation and pharmaceutical compositions in which they are present

摘要

The present invention relates to quaternary ammonium salts of the formula <IMAGE> (I) in which: J is either a group Ar-CXX'-CX'' or a group Ar-(CH2)xCH1, in which: Ar is a substituted or unsubstituted phenyl, a cycloalkyl, a pyridyl or a thienyl; X is hydrogen; X' is hydrogen or is combined with X'' below to form a carbon-carbon bond, or else X and X' together form an oxo group; X'' is hydrogen or forms a carbon-carbon bond with X'; X is zero or one; and X1 is hydrogen (n=0), a hydroxyl, an alkoxy, an acyloxy, a carboxyl, a carbalkoxy, a cyano or an alkoxyamino group; Q is an alkyl group or a benzyl group; A(-) is an anion; m is 2 or 3; Ar', R, T and Z are as defined in the specification, are neurokinin receptor antagonists.