发明名称 |
Method to enhance thrombomodulin APC generation using cationic proteins |
摘要 |
A method of inhibiting blood coagulation in a patient is provided. This method involves administering to the patient an effective anticoagulant amount of a cationic protein; wherein the cationic protein has an isoelectric point of at least about 7.4, and is capable of enhancing the production of activated protein C by a thrombomodulin-thrombin complex by a factor of at least about two. A particularly preferred cationic protein is purified Platelet Factor 4.
|
申请公布号 |
US5674489(A) |
申请公布日期 |
1997.10.07 |
申请号 |
US19960698329 |
申请日期 |
1996.08.15 |
申请人 |
REGENTS OF THE UNIVERSITY OF MINNESOTA |
发明人 |
SLUNGAARD, ARNE |
分类号 |
A61K38/16;A61K38/17;A61K38/19;(IPC1-7):A61K38/48;A61K38/02;A61K38/36 |
主分类号 |
A61K38/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|