发明名称 |
Enhanced loading of solutes into polymer gels and methods of use |
摘要 |
A method of loading a drug into a crosslinked polymer network and protecting the drug from the effects of inactivation is described. The method includes the steps of contacting a biologically active solute (e.g. drug) with: (i) a gel network; (ii) a loading polymer that is somewhat immiscible with the gel; and (iii) a salt, under conditions sufficient for the biologically active solute to selectively partition into the gel and the salt and the loading polymer to be entrained in the gel. A drug delivery system including a polymer gel network and the drug to be delivered is also described. The system also includes a salt and/or a loading polymer. The system protects the drug from loss of activity. In one embodiment, the polymer gel network is capable of expanding or collapsing in response to a change in an environmental condition to which the gel is exposed, the expanding or collapsing sufficient to release the drug into an environment of use.
|
申请公布号 |
US5674521(A) |
申请公布日期 |
1997.10.07 |
申请号 |
US19950425275 |
申请日期 |
1995.04.20 |
申请人 |
UNIVERSITY OF CINCINNATI |
发明人 |
GEHRKE, STEVEN HENRY;LUPTON, E. C.;SCHILLER, MATTHEW E.;UHDEN, LORELLE;VAID, NITIN |
分类号 |
A61K9/20;A61K9/22;A61L15/60;(IPC1-7):A61F2/02;A61K47/30 |
主分类号 |
A61K9/20 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|