发明名称 |
Human cyclin-dependent kinase-like proteins and methods of using the same |
摘要 |
Substantially pure human cyclin-dependent kinase-like proteins PITALRE and PISSLRE and isolated protein complexes that comprise PITALRE or PISSLRE are disclosed. Isolated nucleic acid molecule that encode PITALRE or PISSLRE, or a fragment thereof; recombinant expression vectors that comprise nucleic acid sequences that encode PITALRE or PISSLRE; and host cells that comprise such recombinant expression vectors are disclosed. Oligonucleotide molecules that consist of a nucleotide sequence complementary to a portion of the nucleotide sequence that encodes PITALRE or PISSLRE are disclosed. Antibodies which bind to epitopes on PITALRE or PISSLRE are disclosed. Nucleic acid molecules that comprise a nucleotide sequence that encodes phosphorylation deficient PITALRE or a phosphorylation deficient PISSLRE; recombinant vectors and pharmaceutical compositions that comprise such nucleotide sequences are also disclosed. Methods of identifying compounds which inhibit PITALRE activity are disclosed.
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申请公布号 |
US5674748(A) |
申请公布日期 |
1997.10.07 |
申请号 |
US19950403634 |
申请日期 |
1995.03.14 |
申请人 |
THOMAS JEFFERSON UNIVERSITY |
发明人 |
GIORDANO, ANTONIO |
分类号 |
C12N15/09;A61K31/00;A61K31/70;A61K31/7088;A61K38/00;A61P35/00;C07K14/47;C07K16/18;C07K16/40;C12N1/21;C12N5/10;C12N9/12;C12N15/54;(IPC1-7):C12N1/21;C12N15/63 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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