| 摘要 |
<p>The present invention provides for a compound having the structure: (AA1)n-Cys-(AA2)m wherein n = 0, 1, 2, 3, 4 or 5 and m = 0, 1, 2, 3, 4 or 5, provided the sum of (n + m) is greater than or equal to two and less than or equal to five, if n = 1, (AA1)n = Ala-, if n = 2, (AA1)n = Gln-Ala, if n ≥ 3, (AA1)n = (Xaa)p-Gln-Ala-, and Xaa = any amino acid and wherein if n = n3, p = 1, if n = 4, p = 2, if n = 5, p = 3, if m = 1, (AA2)m = -Arg, if m = 2, (AA2)m = -Arg-Gly, if m ≥ 3, (AA2)m = -Arg-Gly-(Xaa)q, wherein if m = 3, q = 1, if m = 4, q = 2, if m = 5, q = 3. The present invention provides for a method of inhibiting cell death and a method for alleviating symptoms of a neurodegenerative disorder in a subject.</p> |
