发明名称 |
CYCLOSPORIN A FORMULATIONS AS NANOPARTICLES |
摘要 |
Cyclosporin A formulations are provided as amorphous nanoparticle dispersions for physiologic absorption. The compositions have high bioavailability and patient acceptability. By providing for concentrates comprising lower alkanols and a polyoxyalkylene surfactant as a stable dispersion of cyclosporin A, upon introducing the stable dispersion into an aqueous medium, the subject formulation is produced comprising amorphous bioavailable cyclosporin nanoparticles.
|
申请公布号 |
WO9735603(A1) |
申请公布日期 |
1997.10.02 |
申请号 |
WO1997US04627 |
申请日期 |
1997.03.21 |
申请人 |
SANGSTAT MEDICAL CORPORATION;FLOC'H, ROBERT;MERLE, CHRISTIAN |
发明人 |
FLOC'H, ROBERT;MERLE, CHRISTIAN |
分类号 |
A61K9/10;A61K9/48;A61K38/13;A61K47/10;A61K47/14;A61K47/26;(IPC1-7):A61K38/13 |
主分类号 |
A61K9/10 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|