发明名称 |
Microparticle preparation and production thereof |
摘要 |
<p>A novel microparticle preparation comprising microparticles of a polymer which contain a drug and are at least partially or wholly coated with a water-soluble inorganic salt, a water-soluble organic acid or a water-soluble salt of an organic acid, which acts as an agent for preventing aggregation of the microparticle preparation is disclosed. The preparation is produced by spraying a polymer solution containing a drug and a solution or dispersion of a water-soluble inorganic salt, a water-soluble organic acid or a water-soluble salt of an organic acid from different nozzles and contacting them with each other in a spray dryer. In this procedure, if desired, a non-ionic surfactant may be added to the solution of the water-soluble inorganic salt, the water-soluble organic acid or the water-soluble salt of organic acid, or a solution of non-ionic surfactant may be sprayed from the other nozzle simultaneously.</p> |
申请公布号 |
EP0580428(B1) |
申请公布日期 |
1997.10.01 |
申请号 |
EP19930305761 |
申请日期 |
1993.07.22 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
AKAGI, YASABURO;TAKECHI, NOBUYUKI;NONOMURA, MUNEO |
分类号 |
A61K9/16;A61K9/50;(IPC1-7):A61K9/50 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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