发明名称 |
METHOD OF SEPARATING AND PURIFYING TRH ANALOGS AND PROCESS FOR PRODUCING SOLVATES OF TRH ANALOGS |
摘要 |
<p>A method for separation and purification of a TRH derivative, which is characterized by introducing an imino-protecting group into the histidine moiety of a TRH analog to give an imino-protected compound of the following formula ÄIIÜ <CHEM> wherein Y is an imino-protecting group, and separating-purifying same in an organic solvent. According to the present invention, compound ÄIÜ can be separated and purified efficiently from the reaction mixture by a simple and easy method. The compound ÄIÜ thus obtained can be recrystallized with ease from water and the like as a solvate, thereby permitting easy production of solvate ÄIIIÜ at high purity and in high yields.</p> |
申请公布号 |
EP0749978(A4) |
申请公布日期 |
1997.10.01 |
申请号 |
EP19950906536 |
申请日期 |
1995.01.27 |
申请人 |
JAPAN TOBACCO INC. |
发明人 |
SAKUMA, KAZUHIKO;HARA, KATSUYOSHI;HARUTA, JUNICHI;SAITOH, AKIRA;UCHIDA, ITSUO |
分类号 |
C07K5/078;(IPC1-7):C07K5/078;C07K1/14 |
主分类号 |
C07K5/078 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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