发明名称 |
POLYMER MICROSPHERES AND A METHOD OF PRODUCTION THEREOF |
摘要 |
PCT No. PCT/GB95/00686 Sec. 371 Date Mar. 4, 1997 Sec. 102(e) Date Mar. 4, 1997 PCT Filed Mar. 27, 1995 PCT Pub. No. WO95/26376 PCT Pub. Date Oct. 5, 1996The invention relates to microspheres which are suitable for biomedical uses which have a diameter in the range of 10 nm to 2 mm and which comprise a substantially spherical core particle of a non-water-soluble polymer and an outer surface layer consisting substantially of a water-soluble polymer. The water-soluble polymer is conjugated to polyethylene glycol and the non-water-soluble core particle is attached to the water-soluble polymer by the polyethylene glycol moiety. The microspheres are prepared by dissolving the non-water-soluble polymer in a suitable first solvent, dispersing the polymer solution in a solution of the PEG/water-soluble polymer conjugate and evaporating the first solvent to form microspheres in which the PEG anchors the water-soluble polymer to the core particle. |
申请公布号 |
EP0797615(A2) |
申请公布日期 |
1997.10.01 |
申请号 |
EP19950912372 |
申请日期 |
1995.03.27 |
申请人 |
THE UNIVERSITY OF NOTTINGHAM;UNIVERSITY OF GENT |
发明人 |
COOMBES, ALLAN, GERALD, ARTHUR;DAVIS, STANLEY, STEWART;SCHACHT, ETIENNE, HONORE |
分类号 |
A61K9/14;A61K9/16;A61K9/51;C08J3/00;C08J3/12;C08J3/14;(IPC1-7):C08J3/12 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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