| 摘要 |
A method of diagnosing of mycobacterial disease in a patient typically caused by Mycobacterium tuberculosis (TBC) or Mycobacterium avium complex (MAC), is disclosed. In a sample of feces, sputum or urine from said patient, the presence of a mycobacterial antigen selected from the group consisting of lipoarabinomannans (LAM), arabinomannans (AM), and fragments of LAM and AM, is determined, e.g. by the use of polyclonal or monoclonal antibodies directed against said mycobacterial antigen, and an assay detecting antigen/antibody complexes formed. The sample of feces, sputum or urine can be pretreated by heat sterilization. Further, an immunoassay kit for use in the method of diagnosing, and a method of monitoring the effects of therapeutic treatment of a mycobacterial disease, are described. |
