N(1) substituted pyrazino Ä2,3-cÜ-1,2,6-thiadiazine 2,2-dioxides and their use as pharmaceuticals

摘要

1N substituted pyrazino[2,3-c]-1,2,6-thiadiazine 2,2-dioxides of formula I where: R1 and R2, which may be the same or different, are members of the group formed by hydrogen, straight or branched chain alkyl aryl, trifluoromethyl, halogen, oxo, amino, carboxamido and alkoxycarbonyl; R3 is a member of the group formed by straight or branched chain alkyl, dialkylaminoethyl, aralkyl, alkoxycarbonylmethyl, carboxymethyl and hydroxyethyl; and R4 and R5, which may be the same or different, are members of the group formed by hydrogen, straight or branched chain alkyl and aralkyl, hydroxyalkyl, amino, aminoalkyl, alkylaminoalkyl; and a process for the preparation thereof.