发明名称 |
Certain phosphonomethyl-pentanedioic acid derivatives thereof |
摘要 |
The present disclosure relates to dipeptidase inhibitors, and more particularly, to N-Acetylated alpha -Linked Acidic Dipeptidase (NAALADase) enzyme inhibitors which are proposed as novel agents for the treatment of prostate cancer. NAALADase is enzyme which is a membrane-bound metalloprotease which hydrolyzes the dipeptide, N-acetyl-L-aspartate-L-glutamate (NAAG) to yield glutamate and N-acetylaspartate. The compounds of the present invention include phosphinic acid derivatives that inhibit NAALADase enzyme activity and which have been found useful for inhibiting the growth of prostate cancer cells.
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申请公布号 |
US5672592(A) |
申请公布日期 |
1997.09.30 |
申请号 |
US19960665776 |
申请日期 |
1996.06.17 |
申请人 |
GUILFORD PHARMACEUTICALS INC. |
发明人 |
JACKSON, PAUL F.;SLUSHER, BARBARA S. |
分类号 |
C07F9/30;C07F9/40;C07F9/44;C07F9/58;C07F9/655;(IPC1-7):A61K31/66;C07F9/38;C07F9/572 |
主分类号 |
C07F9/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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