| 摘要 |
PCT No. PCT/US94/00148 Sec. 371 Date Jun. 29, 1995 Sec. 102(e) Date Jun. 29, 1995 PCT Filed Jan. 5, 1994 PCT Pub. No. WO94/15587 PCT Pub. Date Jul. 21, 1994A composition including a polyester containing one or more free COOH groups ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein the polyester contains a member selected from the group of L-lactic acid, D-lactic acid, DL-lactic acid, epsilon -caprolactone, p-dioxanone, epsilon -caprolic acid, alkylene oxalate, cycloalkylene oxalate, alkylene succinate, beta -hydroxybutyrate, substituted or unsubstituted trimethylene carbonate, 1,5-dioxopan-2-one, 1,4-dioxepan-2-one, glycolide, glycolic acid, L-lactide, D-lactide, DL-lactide, meso-lactide, and any optically active isomers, racemates or copolymers thereof, and at least 50%, by weight, of the polypeptide present in the composition is ionically conjugated to said polyester.
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