发明名称 |
Anthracycline conjugates having a novel linker and methods for their production |
摘要 |
<p>The present invention relates to novel conjugates, methods for their production, pharmaceutical compositions and methods for delivering cytotoxic anthracyclines to a selected population of cells desired to be eliminated. The anthracycline conjugates comprise at least one anthracycline molecule linked to a ligand that is reactive with a cell population to be eliminated, the anthracycline having a keto group at the C-13 position, and being attached to the ligand via a linker arm and being bound to that linker arm via an acid-sensitive acylhydrazone bond at the 13-keto position of the anthracycline. The conjugates of the invention are therefore useful in antibody- or ligand-mediated drug delivery systems for the preferential killing of a selected cell population in the treatment of diseases such as cancers and other tumors, non-cytocidal viral or other pathogenic infections, and autoimmune disorders.</p> |
申请公布号 |
GR3023784(T3) |
申请公布日期 |
1997.09.30 |
申请号 |
GR19970401423T |
申请日期 |
1997.06.13 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
GREENFIELD, ROBERT S.;BRASLAWSKY, GARY R.;OLECH, LEE J.;KANEKO, TAKUSHI;KIENER, PETER A. |
分类号 |
A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61K38/00;A61K38/16;A61K38/22;A61K38/28;A61K39/395;A61K47/48;A61P31/00;A61P35/00;A61P37/02;C07H15/252;(IPC1-7):A61K47/48 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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