发明名称 |
DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
摘要 |
<p>Compounds of formula (I): <CHEM> [wherein R<1> represents a group of formula (II) or (III): <CHEM> R<2> is hydrogen or a group of formula -OR<3>; R<3>, R<3a> and R<3b> are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulphonyl, halogenated alkanesulphonyl or arylsulphonyl; R<4> is hydrogen or a carboxy-protecting group; R<5> is alkyl, alkenyl, alkynyl, aryl, aralkyl or a fused polycycle; and W is alkylene] and their salts and esters have the ability to inhibit the synthesis of cholesterol, and can thus be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.</p> |
申请公布号 |
IL108432(A) |
申请公布日期 |
1997.09.30 |
申请号 |
IL19940108432 |
申请日期 |
1994.01.25 |
申请人 |
SANKYO COMPANY LIMITED |
发明人 |
|
分类号 |
A61K31/19;A61K31/015;A61K31/121;A61K31/215;A61K31/22;A61K31/275;A61K31/365;A61K31/366;A61P3/06;A61P9/00;C07C67/08;C07C69/03;C07C69/708;C07C69/712;C07C69/73;C07C69/734;C07C69/736;C07C205/34;C07C205/35;C07C217/84;C07C255/54;C07D309/30;C07F7/18;C12P7/40;C12P7/62;C12P17/06;C12R1/465;(IPC1-7):C07C65/21;C07D319/14;C07D317/44;C07C309/72;C07C309/65;C07C255/61;C07C255/49;C07C239/08;C07C229/52;C07C225/22;C07C223/06;C07C217/78;C07C217/76;C07C205/57;C07C205/45;C07C205/44;C07C205/32;C07C69/013;C07C65/32;C07C65/30;A61K31/695;A61K31/335;A61K31/255;C12P7/42;C07D407/00;C07D321/00 |
主分类号 |
A61K31/19 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|