发明名称 |
REVERSED PHASE CHROMATOGRAPHIC PROCESS |
摘要 |
<p>An improved process for the reversed phase chromatographic decolorization, separation, and purification of water-soluble, nonionic contrast media compounds from solutions containing nonionic compound impurities involves the steps of (a) packing a chromatographic column with a chromatographic packing material; (b) passing through the column a solution containing a water-soluble, nonionic contrast media compound and nonionic compounds as impurities at a loading ratio between approximately 10 to 1 and 1.5 to 1 wt. packing material/total wt. nonionic compounds; and (c) eluting the column to produce an eluate containing substantially pure, water-soluble, nonionic contrast media compound or MRI agent. The process can be economically practiced on a factory scale and efficiently removes non-polar impurities difficult to remove by conventional methods.</p> |
申请公布号 |
GR3023716(T3) |
申请公布日期 |
1997.09.30 |
申请号 |
GR19970401357T |
申请日期 |
1997.06.10 |
申请人 |
MALLINCKRODT, INC. |
发明人 |
DORAN, NARCISCO, O.;DUNN, THOMAS, J.;KNELLER, MILLS, T.;LIN, YOULIN;WONG, DAVID, MING-LEE;WHITE, DAVID, H. |
分类号 |
B01D15/00;B01D15/08;C07C231/24;C07C237/46;(IPC1-7):B01D15/08 |
主分类号 |
B01D15/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|