| 摘要 |
<p>The invention discloses a purification process through ultrafiltration and/or nanofiltration with the exclusion of molecular weights higher than 10,000 Dalton and preferably higher than 2,000 Dalton. By using this technique it is possible to obtain for example cephalosporine-G with an enhanced purity grade represented by 6-8 % of power increase of HPLC, with a decrease of 50 % in absorbance. The invention provides for the use of the purified products, in a direct form, without requiring any intermediary isolation, in the synthesis of other antibiotic compounds.</p> |
