BIS-HETEROCYCLIC DERIVATIVES

摘要

Compounds of general formula (I) wherein R?1, R2, R3, R4, R5, R6, R7, and R8¿ each independently are: hydrogen; halogen; nitro; nitroso; cyano; a group -CO-Z-R10, -CS-Z-R10, -SO2-Z-R?10?, -C(NH)-NR?10R11, -CO-R10, -SO-R10, -SO¿2-R10, -Z-CO-R10, -Z-CO-Z-R10, -Z-CS-R10 or -Z-SO¿2?-R?10, -O-R10, -S-R10 or -NR10R11¿, wherein each Z independently is -O-, -S- or -N(R11)-; optionally substituted, linear or branched C¿1-10?alkyl, C2-10alkenyl, C4-10alkadienyl, C6-10alkatrienyl, C2-10alkynyl, C3-8cycloalkyl, C3-8cycloalkenyl, C4-8cycloalkadienyl, C6-8cycloalkatrienyl or C3-8cycloalkyl-C1-4alkyl; or R?3 and R7¿, and/or R?4 and R8¿ together form a bond; or R?1 and R2¿, and/or R?5 and R6¿ together form a bivalent group -(CH¿2?)n- wherein n is an integer from 3 to 5, or a bivalent group -Z-(C(R?15)¿2)m-Z- wherein m is an integer from 1 to 3; X?1 and X2¿ each independently is O, S, or N(R12); and Y?1 and Y2¿ each independently is N or C(R13); with the proviso that when X?1-Y1 and X2-Y2¿ are both O-N, and R?3 and R7, and R4 and R8¿, each together form a bond, then at least one of R?1, R2, R5, and R6¿ is different from hydrogen, or that R?1 and R6¿ are both different from nitro, methyl and unsubstituted phenyl; and physiologically acceptable salts thereof. Such compounds have anti-cancer properties.