Binding sequence in bone sialoprotein for S. aureus

摘要

A polypeptide of bone sialoprotein selected from an amino acid sequence within position 42 to position 85 in the amino acid sequence set forth in SEQ ID NO: 10 and comprising the amino acid sequence LKRF, said polypeptide having the ability to inhibit the binding of bone sialoprotein to staphylococcal cells, or functional equivalents comprising the sequence LKRF. The invention also comprises the polypeptide for use as a medicament and use of the polypeptide for the manufacture of a medicament for inhibiting staphylococcal adhesion to tissues or implants. Further a method of inhibiting staphylococcal adhesion to tissues or implants of a mammal, including man, is included.