摘要 |
<p>The present invention relates to devices and methods for enhancing the rate and efficacy of permeation of a drug into and through skin and into the circulatory system utilizing ultrasound. A transducer receives electrical signals from a generator and transforms it into ultrasound at a preselected frequency. The ultra sound is transmitted from the transducer to the application site via an acoustic transmission line. In a closed loop embodiment a sensor, e.g. a temperature sensor, provides a feedback signal via a control electronic circuit to the generator.</p> |