CYSTATIN B MUTANTS

摘要

An isolated nucleic acid molecule, wherein the molecule contains: (1) a first sequence consisting of human cystatin B genomic DNA as set forth in figure 3 (SEQ ID NO:1); (2) a second sequence, wherein said second sequence is a subsequence of said first sequence, is at least 10 nucléotides in length, and is not present in human cystatin B cDNA; (3) a third sequence in which at least one nucleotide of said first or second sequences is replaced by a different nucleotide; or (4) a fourth sequence complementary to any of said first, second or third sequences; with the proviso that (i) if said molecule is an RNA molecule, U replaces T in said sequence of said molecule, and (ii) said third sequence is at least 95 % identical to said first or second sequence.