发明名称 |
PROCESS FOR PRODUCING EFONIDIPINE HYDROCHLORIDE PREPARATIONS |
摘要 |
The present invention can form an amorphous solid dispersion of efonidipine hydrochloride having a high intestinal absorbability which can be formed by subjecting a mixture containing efonidipine hydrochloride of formula (I), hydroxypropylmethylcellulose acetate succinate and optionally a thermostabilizer to a step A of heat treatment at from 85 to 140 ~C or mechanochemical treatment at from 0 to 140 ~C, and then to a step B of dipping treatment into a water-containing solution, impregnation treatment with a water-containing solution or contacting treatment with a water vaporcontaining gas; or treating the above-mentioned mixture with a hot steam at from 100 to 140 ~C and a high pressure. Further, in the above-mentioned step A, the mixture is subjected to high frequency heating, making it possible to give a solid dispersion of efonidipine hydrochloride having a high intestinal absorbability without using the step B. This process is quite advantageous in the production in that the use of an organic solvent is not required.
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申请公布号 |
CA2248582(A1) |
申请公布日期 |
1997.09.25 |
申请号 |
CA19972248582 |
申请日期 |
1997.03.17 |
申请人 |
NISSAN CHEMICAL INDUSTRIES, LTD.;ZERIA PHARMACEUTICAL CO., LTD. |
发明人 |
NISHIYAMA, TETSUYKI;OKABE, TOSHIO;BUNRIN, TOYOHIKO;ODA, TOSHIHISA;MIYAMOTO, MISAO |
分类号 |
A61K9/14;A61K9/16;A61K31/66;A61K31/675;(IPC1-7):A61K31/675 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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