METHOD OF TREATING NEOPLASTIC CELLS WITH PROSTAGLANDIN

摘要

The invention is directed to a method of increasing ionizing radiation's cytotoxic effects on a neoplasm in a subject by increasing the neoplasm's sensitivity to ionizing radiation, comprising administering a therapeutically effective amount of prostaglandin to the subject, and subjecting the neoplasm to a therapeutically effective amount of ionizing radiation, thereby increasing the cytotoxic effects of the ionizing radiation on the neoplasm. The invention is further directed to a method of reducing the therapeutically effective amount of ionizing radiation required to treat a neoplasm in a subject, compared to treating with ionizing radiation alone, comprising administering a therapeutically effective amount of prostaglandin to the subject, thereby reducing the therapeutically effective amount of ionizing radiation required to treat the neoplasm in the subject, compared to treating with ionizing radiation alone, and subjecting the neoplasm in the subject to the reduced therapeutically effective amount of ionizing radiation. The invention is also directed to a method of treating a neoplasm in a subject, comprising administering a therapeutically effective amount of prostaglandin and administering a therapeutically effective amount of cisplatin to the subject, wherein the therapeutically effective amount of the platinum-based anti-tumor agent is less than 60mg/meter<2>.