Superparamagnetische Teilchen mit vergrößerter R¶1¶-Relaxivität, Verfahren zur Herstellung und deren Verwendung

摘要

The invention relates to super-paramagnetic single domain particles with increased R1 relaxivity and with surface-stabiliser substances. The particles are characterised in that they: consist of iron hydroxide, ferric hydrate, iron oxide, iron mixed oxide or iron; are between 1 and 10 nm in size, the mean particle diameter d50 being 2-4 nm; and have increased R1 reflexivity of between 2 and 50, the ratio of the relaxivities R2/R1 being less than 5. Stabiliser substances are bound to the particle surfaces; these prevent aggregation and sedimentation under gravity or in a magnetic field. If necessary, the particles can also contain a tissue-specific binding substance, a pharmacologically active substance, pharmacologically active cells, a pharmacologically active complexing agent, a cell fusion-promoter or gene-transfer mediator, or mixtures of these substances. The novel particles can be used for attacking tumours, boosting immunity, for cell fusion, gene transfer, or as contrasting agents in magnetic resonance diagnostics using magnetic fields where necessary.