PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL IN THE SYNTHESIS OF CEPHALOSPORINS
摘要
<p>A process is described for preparing 3-exomethylene cephalosporanic acid derivatives for use in the synthesis of cephalosporin antibiotics such as ceftibuten. The process comprises electrochemical reduction of a compound of the formula (IV) <IMAGE> (IV) wherein: R3 is CH3C(O)-; <IMAGE> is an optional sulfoxide group; n is 2 or 3; R1 is H and R is H or NHR2, where R2 is H or a protecting group selected from C6H5CH2OC(O)-, C6H5C(O)- or C1-C6 alkoxy-C(O)-; or wherein R and R1 together with the carbon atom to which they are attached comprise -C(O)-, and produces the desired 3-exomethylene compounds with low levels of the corresponding 3-methyl tautomers.</p>
申请公布号
EP0796261(A1)
申请公布日期
1997.09.24
申请号
EP19950942460
申请日期
1995.12.06
申请人
SCHERING CORPORATION;ANTIBIOTICOS
发明人
WALKER, DEREK;LEE, JUNNING;MARTIN, CHARLES, R.;ZHANG, HAIYAN;SOGLI, LORIS;BERNASCONI, ERMANNO;MENON, VINOD, P.