| 摘要 |
Optically active or racemic compounds represented by the formula <IMAGE> where R1 is C1 to C4 straight chain or branched alkyl; R2 is selected from the group consisting of H, -OR1, -SR1, -NH(R1), -N(R4)(R5), aminocarbonyl, halogen, and -CN, where R4 and R5 are independently C1 to C6 straight chain or branched alkyl, or taken together form a 3- to 7-membered heterocycloalkyl substituent, such heteroatom selected from the group consisting of oxygen, nitrogen and sulfur, optionally including an additional heteroatom which is selected from the group consisting of nitrogen, oxygen, and sulfur; R3 is cyclopentyl or: <IMAGE> where R' and R'' are independently H, =O, -OH, or -NH2, with the proviso that R' and R'' can be taken together form the following structure as R3: <IMAGE> where R''' is -OH or -NH2; and with the further proviso that when R3 is cyclopentyl or norbornyl, then R2 cannot be H or halogen; and pharmaceutically-acceptable salts thereof. These compounds are useful as diuretics, renal protectives against acute or chronic renal failure, as well as agents to facilitate recovery from coma, to improve the therapeutic outcome resulting from defibrillation or cardiopulmonary resuscitation by preventing post-resuscitation bradycardia, bradyarrhythmia and cardioplegia, to restore cardiac function following a cardioplegic procedure, and to treat or prevent intermittent claudication.
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