| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new hepatocytic growth factor, having a specific amino acid sequence, available in a large amount according to a recombinant DNA technique and useful as a therapeutic agent, etc., for hepatopathy such as a hepatic regeneration promoter, a hepatic function improver, a therapeutic agent for hepatitis or a suppressant for cirrhosis. SOLUTION: This new hepatic growth factor has an amino acid sequence represented by the formula and the possibility of providing a therapeutic agent, etc., for hepatopathy such as a hepatic regeneration promoter, a hepatic function improver, a therapeutic agent for hepatitis or a suppressant for cirrhosis. The hepatocytic growth factor is obtained in a large amount by screening a hepatic cDNA library derived from a human with probe, comprising a peptide fragment prepared by treating a human hepatic cell growth factor (hHGF) isolated from a blood plasma of a patient suffering from fulminant hepatitis with an Achromobacter protease I, etc., integrating the resultant gene capable of coding the hepatocytic growth factor into a vector and expressing the gene in the host cell. |
