Muscular dystrophy, stroke, and neurodegenerative disease diagnosis and treatment

摘要

Nitric oxide, neuronal nitric oxide synthase, neuronal nitric oxide synthase binding proteins, their inhibitors and a method of use of neuronal nitric oxide synthase, its binding proteins and their inhibitors for diagnosis and treatment of muscular dystrophy, stroke and other neurodegenerative diseases. A diagnostic assay for detection of absence of dystrophin or its mutated forms, neuronal nitric oxide synthase or its binding proteins. A method for treatment of muscular dystrophies by restoration of a functional dystrophin molecule in dystrophic muscles using gene therapy. Neuronal nitric oxide binding proteins PSD-95 and PSD-93 involved in management of stroke and other neurodegenerative diseases. The cloning and expression of the neuronal nitric oxide synthase binding proteins.