发明名称 |
Taxoid anti-tumor agents and pharmaceutical compositions thereof |
摘要 |
<p>This invention relates to a taxoid of the formula (I): wherein R1 is a C3-C5 alkyl or alkenyl or trifluoromethyl radical; R2 is a C3-C5 branched alkyl radical; R3 and R4 are independently selected from hydrogen and hydroxyl protecting groups including functional groups which increase the water solubility of the taxoid antitumor agent; R5 is a hydrogen, an acyl radical, or an alkoxylcarbonyl or carbamoyl radical; and R6 is an acyl radical. The compounds of formula I are useful as antitumor agents or their precursors. This invention also relates to a pharmaceutical composition having antineoplastic activity comprising the compound of formula (I) and a physiologically acceptable carrier and method of treatment using the compound of formula I.</p> |
申请公布号 |
AU2137497(A) |
申请公布日期 |
1997.09.22 |
申请号 |
AU19970021374 |
申请日期 |
1997.03.04 |
申请人 |
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK |
发明人 |
IWAO OJIMA |
分类号 |
A61K31/335;A61K31/337;A61P35/00;C07D305/14;C07F7/18 |
主分类号 |
A61K31/335 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|