| 摘要 |
PROBLEM TO BE SOLVED: To enhance the processing capability furthermore in a multi-capillary DNA sequencer. SOLUTION: The angles or excited optical beams E from optical exciting lasers 2a and 2b are changed at a planar mirror 3. The beam is expanded in a beam expander 4. The light is condensed in the line shape by a cylindrical lens 5. The light is applied on the capillary array of a migrating part 1. Then, the mark fluorescent material of the DNA fragment migrating in the capillary array is excited. The generated fluorescence is accepted as the image with a macro-lens 6 together with the excited light. The excited-light component is shielded by a notch filter 8 through a slit 7 and divided in a concave grating 9. The image of the spectroscoped fluorescent light at the capillary array is formed on a detector 10. In a CPU 12, the position data of the capillary array are obtained as the data on the detector 10 in the (x) direction, and the spectroscopic signal at each capillary position is obtained in the λ direction. The alignment of the base of the DNA sample at each capillary is obtained accompanied by the elapse of time. |
