发明名称 |
PROCESS FOR PREPARING P-NITROAROMATIC AMIDES AND PRODUCTS THEREOF |
摘要 |
<p>A process for preparing p-nitroaromatic amides is provided which comprises contacting an amide and nitrobenzene in the presence of a suitable solvent system, and reacting the amide and nitrobenzene in the presence of a suitable base and a controlled amount of protic material at a suitable temperature in a confined reaction zone. The p-nitroaromatic amides of the invention can be reduced to p-aminoaromatic amides. In one embodiment, the p-aminoaromatic amide is further reacted with ammonia under conditions which produce the corresponding p-aminoaromatic amine and the amide starting material which can be recycled or with water in the presence of a suitable basic or acidic catalyst under conditions which produce the corresponding p-aminoaromatic amine and the acid or salt thereof corresponding to the amide starting material. In another embodiment, the p-aminoaromatic amine is reductively alkylated to produce alkylated p-aminoaromatic amine. The p-nitroaromatic amide can be reacted with ammonia under conditions which produce the corresponding p-nitroaromatic amine and the amide starting material which can be recycled or with water in the presence of a suitable basic or acidic catalyst under conditions which produce the corresponding p-nitroaromatic amine and the acid or salt thereof corresponding to the amide starting material. In one embodiment, the p-nitroaromatic amine is reduced to produce p-aminoaromatic amine. In another embodiment, the p-aminoaromatic amine is reductively alkylated to produce alkylated p-aminoaromatic amine. In another embodiment, the p-nitroaromatic amine is reductively alkylated to produce p-aminoaromatic amine.</p> |
申请公布号 |
EP0662074(B1) |
申请公布日期 |
1997.09.17 |
申请号 |
EP19930910797 |
申请日期 |
1993.04.26 |
申请人 |
MONSANTO COMPANY |
发明人 |
STERN, MICHAEL, KEITH;BASHKIN, JAMES, KEANE |
分类号 |
C07C209/50;C07C209/36;C07C209/62;C07C211/50;C07C211/51;C07C211/52;C07C231/08;C07C231/12;C07C233/12;C07C233/56;C07C233/64;C07C233/65;C07C233/66;C07C233/80;C07C235/56;C07C237/40;(IPC1-7):C07C231/06 |
主分类号 |
C07C209/50 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|