Substituted 4-thio pyridones

摘要

Novel cephem derivatives represented by the general formula <IMAGE> in which the Acyl substituent is a group of the formula <IMAGE> wherein Ar is a lipophilic optionally substituted phenyl, naphthyl or pyridyl group; R1 represents either the residue of a heterocyclic amino acid or a C2-C10 alkyl group substituted by both a carboxyl group and a group of the formula -NR9R10 or <IMAGE> in which R9 and R10 are each independently hydrogen or C1-C6 alkyl, said C2-C10 alkyl group being optionally interrupted by one or more nitrogen atoms or carbonyl groups, and R2 and R3 are each independently hydrogen, alkyl or aminoalkyl are gram-positive antibacterial agents, especially useful in the treatment of diseases caused by methicillin-resistant Staphylococcus aureus (also referred to below as MRSA or methicillin-resistant S. aureus).