GENE THERAPY FOR THE TREATMENT OF SOLID TUMORS USING RECOMBINANT ADENO-ASSOCIATED VIRUS VECTORS
摘要
The use of recombinant adeno-associated virus (AAV) virions for the treatment of solid tumors is disclosed. The invention provides for the use of recombinant AAV virions to deliver an AAV vector containing a drugsusceptibility gene and a second gene capable of providing an ancillary effect to solid tumor cells. The second gene can be used to enhance the immunogenicity of the transduced tumor cell. Alternatively, the second gene can be used to provide a tumorstatic effect. The invention also provides for the use of recombinant AAV virions to deliver an interferon gene, or a tumor suppressor gene to provide a therapeutic effect in a transduced tumor cell.
申请公布号
CA2247806(A1)
申请公布日期
1997.09.12
申请号
CA19972247806
申请日期
1997.03.06
申请人
AVIGEN, INC.;OKADA, HIDEHO;MIZUNO, MASAAKI;YOSHIDA, JUN
发明人
OKADA, HIDEHO;MIZUNO, MASAAKI;YOSHIDA, JUN;KURTZMAN, GARY J.;COLOSI, PETER C.