发明名称 SYNTHESIS OF ISOIMIDE OF CHLORINS AND BACTERIOCHLORINS AND THEIR USE FOR DIAGNOSIS AND TREATMENT OF CANCER
摘要 Compounds having utility as light absorbing compounds, especially in the area of photodynamic therapy. Such compounds have formula (I), where z is = 0 or NR14; R14 is alkyl or substituted alkyl, R1 is an amino acid group, a polyamine group, a polyether group or OR13 where R13 is alkyl; R4 through R11 are -H, -OH, alkyl, alkylene, -OR16 where R16 is H, alkyl or aryl, or a carbonyl containing group, provided that: R4 may be taken together with R5 to form =O; R6 may be taken together with R7 to form =O; R8 may be taken together with R9 to form =O; R10 may be taken together with R11 to form =O; and R4 and R7 may together form a chemical bond and R8 and R11 may together form a chemical bond; and R12 is hydrogen or lower alkyl; provided that if one z is 0, the other z is -NR14.
申请公布号 WO9732885(A1) 申请公布日期 1997.09.12
申请号 WO1997US03891 申请日期 1997.03.07
申请人 HEALTH RESEARCH, INC. 发明人 PANDEY, RAVINDRA, K.;KOZYREV, ANDREI, N.;DOUGHERTY, THOMAS, J.
分类号 A61K41/00;C07D471/22;C07D491/22;(IPC1-7):C07D487/22 主分类号 A61K41/00
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