| 摘要 |
<p>Compounds of formula (I), wherein one of U and V is -CHR2-, and the other of U and V is selected from -N(COR4)-, -CH(COR4)-,-N(SO¿2R?4)- and -CH(SO¿2R?4)-, in which R2 is H, -COOR?5, -CONR6R7¿ or -COR?7 and R4¿ is H, C¿1? to C6 hydrocarbyl (in which up to three of the carbon atoms may be replaced by a nitrogen, oxygen or sulphur atom), or a group of the formula -Q-R?16¿ wherein Q is a bond, -NR17- (in which R17 is H or C¿1? to C3 alkyl) or -O-, and R?16¿ is aryl, substituted aryl, arylalkyl or (substituted aryl)alkyl; R is independently C¿1? to C3 alkyl; R?1¿ is H or C¿1? to C15 hydrocarbyl wherein one or more hydrogen atoms may be replaced by halogen atoms, and one carbon atom may be replaced by a nitrogen, oxygen or sulphur atom; R?3¿ is independently halo, alkyl, alkoxy, -NO¿2?, -NH2 or -NHCOR?5¿; X is H and Y is H or C¿1? to C10 hydrocarbyl wherein one or more hydrogen atoms may be replaced by halogen atoms, and one carbon atom may be replaced by a nitrogen, oxygen or sulphur atom; or X and Y together are =O or =CH2; Z is H, C1 to C15 hydrocarbyl (in which one or more hydrogen atoms may be replaced by a halogen atom, and up to three of the carbon atoms may be replaced by a nitrogen, oxygen or sulphur atom), or -(CHR?18)¿m-R8 (wherein R18 is H or C¿1? to C3 alkyl and R?8¿ is phenyl, substituted phenyl or a group of the formula -COOR9 or -CONR9R10, in which R?9 and R10¿ are independently H or C¿1? to C6 alkyl, or R?9 and R10¿ together form a propylene, butylene, pentylene or hexylene group); m is from 1 to 3; and n and p are independently from 0 to 3, and pharmaceutically acceptable salts thereof are ligands at gastrin and/or cholecystokinin receptors.</p> |
