RECOMBINANT LIVE FELINE IMMUNODEFICIENCY VIRUS AND PROVIRAL DNA VACCINES

摘要

This invention discloses live-attenuated feline immunodeficiency virus (FIV), and recombinant vectors for producing them, useful as vaccines and therapeutic agents against FIV and diseases associated with virulent FIV infection. In the recombinant vectors and FIVs, one or more genes, or part of the gene(s), responsible for FIV pathogenesis have been completely or partially rendered nonfunctional, e.g., by full or partial deletion or mutagenesis. These antiFIV vaccines may be given to susceptible hosts in the form of infectious virus or cloned DNA.