PROCESS FOR THE DEACYLATION OF CYCLIC LIPOPEPTIDES

摘要

A cyclic lipopeptide acylase which can effectively remove an acyl side chain from a cyclic lipopeptide, specifically FR901379 represented by general formula (I) or an analogue thereof; and a process for the preparation of a cyclic peptide with the acylase, wherein R<1> is acyl, R<2> is hydroxy or acyloxy, R<3> is hydrogen or hydroxy, R<4> is hydrogen or hydroxy, R<5> is hydrogen or hydroxysulfonyloxy, and R<6> is hydrogen or carbamoyl.