发明名称 |
COMBINATIONS FOR TREATMENT OF PROLIFERATIVE DISEASES |
摘要 |
The invention relates to combinations of PKC-targeted (especially PKC- alpha -targeted) deoxyribo- and ribo-oligonucleotides and derivatives thereof with other chemotherapeutic compounds, as well as to pharmaceutical preparations and/or therapies, in relation to disease states which respond to such oligonucleotides or oligonucleotide derivatives, especially to modulation of the activity of a regulatory protein. In particular, the invention relates to products or combinations comprising antisense oligonucleotides or oligonucleotide derivatives targeted to nucleic acids encoding human PKC and other (preferably standard) chemotherapeutics, either in fixed combination or for chronologically staggered or simultaneous administration, and the combined use of both classes of compounds, either in fixed combination or for chronologically staggered or simultaneous administration, for the treatment of proliferative diseases, especially tumor diseases, that can be treated by inhibition of PKC activity, that is, where the antisense oligonucleotides or oligonucleotide derivatives are targeted to nucleic acids encoding the regulatory protein PKC or active mutated derivatives thereof.
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申请公布号 |
WO9732589(A1) |
申请公布日期 |
1997.09.12 |
申请号 |
WO1997EP00876 |
申请日期 |
1997.02.24 |
申请人 |
NOVARTIS AG |
发明人 |
MUELLER, MARCEL;GEIGER, THOMAS;ALTMANN, KARL-HEINZ;FABBRO, DORIANO;DEAN, NICHOLAS, MARK;MONIA, BRETT;BENNETT, CLARENCE, FRANK |
分类号 |
A61K45/06;(IPC1-7):A61K31/70;A61K31/71;A61K31/66;A61K31/28 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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