Benzothiophenes, formulations containing same, and methods

摘要

This invention provides pharmaceutical benzothiophene compounds of the formula wherein R<1> is hydrogen, hydroxy, C1-C4 alkoxy, wherein Ar is optionally substituted phenyl, or -SO2(C4-C6 straight chain alkyl); R<2> is R<1>, Cl or F; and R<3> and R<4> are, independently, C1-C4 alkyl or combine to form a C4-C6 polymethylene or, together with the nitrogen to which they are attached form morpholine, X is -CH2, -CHOH2-, -O-, or or a pharmaceutically acceptable salt or solvate thereof. s