SATURATED HETEROCYCLIC COMPOUND

摘要

PROBLEM TO BE SOLVED: To obtain a new saturated heterocylcic compound useful for producing preventing agents or therapeutic agent for tachykinin intervened disease such as split personality, etc. SOLUTION: The compound is expressed in formula I (R<1> , R<2> , R<3> are each an aryl, etc.,; A is methylene, etc.,; B is single bond, a 1-4C alkylene, etc.,; D is O or S; E is a 1-6C alkylene, etc., G is a 1-4C alkylene, etc., L is a group having -N(R3 )-), etc., or its pharmacologically permissible salts or esters and other derivatives, e.g. 1- 2-[5-(3,4-dichlorophenyl)-3-[3,4,5 trimethoxybenzoyl]oxazolidin-5-yl]ethyl}-4-phenylpiperidine-4carboxylic acid amide. The compound of formula I is obtained by carrying out the reaction of the compound of formula II (R<8> is H or a protecting group) and the compound of formula III (Y is a halogen) in a solvent in the presence of a base such as triethylamine, etc., at -20 to 100 deg.C, and removing R<8> to obtain the compound of formula IV. Then carrying out the reaction of the compound of formula IV and the compound of formula V in a solvent such as C6 H14 , etc., in the presence of a base such as KI, etc., at 0 to 150 deg.C.