A Shc protein which is characterized as follows: (a) containing a C-terminal Src homology 2 (SH2) domain, a central proline-rich region (CH1), and an N-terminal phosphotyrosine binding (PTB) domain; (b) it is predominantly expressed in the adult brain; (c) it binds through its SH2 domain to proteins containing the consensus sequence pTyr-(hydrophobic/Glu)-(hydrophobic/Met/Tyr/Ile)-(Ile/Leu/Met/Phe/Tyr); and (d) it associates through its PTB domain with proteins containing the consensus sequence Asn-Pro-X-pTyr where X is any amino acid; nucleic acids encoding the protein; and uses of the protein. The Shc proteins mediate signaling from tyrosine kinases in the nervous system.
申请公布号
WO9732020(A2)
申请公布日期
1997.09.04
申请号
WO1997US02997
申请日期
1997.02.28
申请人
MOUNT SINAI HOSPITAL CORPORATION;UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;DER, CHANNING;O'BRYAN, JOHN;PAWSON, ANTHONY;SAXTON, TRACY