发明名称 |
MODIFIED CYTOKINES FOR THERAPEUTIC USE |
摘要 |
The object of the present invention is a new method and new products for the therapeutic use of cytokines. The method is based on the sequential administration of a component A (e.g. a biotinylated antibody) able to deliver onto a particular pathologic target a second component B (e.g. avidin), followed by a component able to bind the component B (component C) (e.g. biotin), conjugated with the cytokines. The method permits to increase the local concentration of the modified cytokines (C-cytokines) through the interaction with the "artificial" receptor B and to cause a local biologic response mediated by "natural" receptors.
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申请公布号 |
CA2247308(A1) |
申请公布日期 |
1997.09.04 |
申请号 |
CA19972247308 |
申请日期 |
1997.02.14 |
申请人 |
FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR |
发明人 |
DELLABONA, PAOLO;SICCARDI, ANTONIO;PELAGI, MICAELA;CASORATI, GIULIA;CORTI, ANGELO |
分类号 |
A61K39/385;A61K31/00;A61K39/395;A61K47/48;A61P35/00;(IPC1-7):C07K14/525;C07K19/00;A61K38/19 |
主分类号 |
A61K39/385 |
代理机构 |
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