Nanokristalline magnetische Eisenoxid-Partikel zur Anwendung in Diagnostik und Therapie
摘要
The invention relates to nanocrystalline magnetic particles consisting of a magnetic iron oxide core composed of Fe3O4, gamma -Fe2O3 or mixtures thereof and of a shell chemisorbed onto this core, to processes for the production of these particles and to the use thereof in medical diagnosis and therapy. The magnetic particles according to the invention are distinguished by the shell material being composed of natural or synthetic glycosaminoglycans and their derivatives with molecular weights of 500 Da to 250,000 Da and being optionally covalently crosslinked by suitable crosslinkers and/or modified by specific additives.
申请公布号
DE59208743(D1)
申请公布日期
1997.09.04
申请号
DE1992508743
申请日期
1992.04.13
申请人
INSTITUT FUER DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITAET BERLIN, 14050 BERLIN, DE
发明人
KRESSE, MAYK, W-1000 BERLIN 19, DE;LAWACZECK, RUEDIGER, DR., W-1000 BERLIN 27, DE;PFEFFERER, DETLEF, W-1000 BERLIN 44, DE