| 摘要 |
PROBLEM TO BE SOLVED: To produce an anticoagulant, capable of being a substitute for a heparin anticoagulant and having excellent safety with relatively high productivity at a low cost by sulfonating a silkworm product. SOLUTION: This anticoagulant comprises a sulfonated silkworm product, preferably a sulfonated fibroin or a sulfonated sericin. The product is preferably obtained by adding concentrated sulfuric acid at 10-90wt.% concentration in an amount of 0.5-500 pts.wt. based on 1 pt.wt. extracted substance to the substance extracted from, e.g. silk yarn or contents of a silk gland of a silkworm such as fibroin or sericin and carrying out the sulfonation treatment at a temperature within the range of 20-100 deg.C for about several tens of minutes to several hours. |
