发明名称 |
Process for making HIV protease inhibitors |
摘要 |
A process for racemization of optically pure or enriched piperazine-2-tert-butylcarboxamide and its derivatives comprising reacting the optically pure or enriched piperazine compound with a racemizing agent selected from a strong base, an anhydrous metal salt or a carboxylic acid, in a solvent at a temperature range of between room temperature and 250 DEG C. The piperazine carboxamide derivatives are key intermediates in the preparation of HIV protease inhibitor compounds, including Compound J.
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申请公布号 |
US5663341(A) |
申请公布日期 |
1997.09.02 |
申请号 |
US19950487903 |
申请日期 |
1995.06.07 |
申请人 |
MERCK & CO., INC. |
发明人 |
ROSSEN, KAI;ASKIN, DAVID;REIDER, PAUL;VARSOLONA, RICHARD J.;VOLANTE, RALPH |
分类号 |
C07D241/14;A61K31/495;A61P31/12;C07D241/04;C07D401/06;C07D405/06;C07D491/04;C07D491/048;(IPC1-7):C07D241/04 |
主分类号 |
C07D241/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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